Endocrine Abstracts

Introduction: Among molecular markers proposed to improve diagnosis of thyroid nodules, mutations in telomerase reverse transcriptase (TERT) promoter have been correlated to malignant tumors with highest recurrence and decreased patient’s survival. This suggests an important role of TERT mutational analysis in the clinical diagnosis and management of thyroid cancer patients. In this study, we investigate the potential use of core needle biopsy (CNB) for the preoperative a...

Background: Molecular analysis of thyroid fine-needle aspiration biopsy (FNA) was proposed to improve indeterminate nodules management. However, sensibility and specificity as well as the cost of molecular diagnostics require to be improved to increase their cost-effectiveness for medical practice setting. Raman spectroscopy (RS) demonstrated ability in separating benign from malignant thyroid lesions in surgically removed tissues, based on specific RS profile. This study aime...